A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 38/00 (2006.01) A61K 39/09 (2006.01) A61K 39/116 (2006.01) A61K 39/38 (2006.01) C07K 1/00 (2006.01) C07K 14/315 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2379327
The present invention relates to synergistic immunogenic combinations containing two or more pneumococcal surface proteins, including PspA and/or PspC and/or PsaA, advantageously, PspA and PsaA. Also provided are methods of intranasal administration of such immunogenic combinations to reduce nasopharyngeal carriage of pneumococci and methods of use of such immunogenic combinations in the prevention and treatment of <i>S.pneumoniae infection</i>.
La présente invention concerne des combinaisons immunogènes synergiques contenant au moins deux protéines de surface pneumococciques, comprenant PspA et/ou PsaA, avantageusement, PspA et PsaA. L'invention concerne également des méthodes d'administration intranasale de ces combinaisons immunogènes pour réduire le transport nasopharyngé de pneumocoques, ainsi que des méthodes d'utilisation de ces combinaisons immunogènes dans la prévention et le traitement d'infections à <i>S. pneumoniae</i>.
Ades Edwin
Briles David E.
Carlone George M.
Huebner Robert C.
Sampson Jacquelyn S.
Aventis Pasteur
Centers For Disease Control And Prevention
Smart & Biggar
Uab Research Foundation
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