Anti-viral pyrimidine derivatives

Details Anti-viral pyrimidine derivatives Anti-viral pyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/505 (2006.01) C07D 239/48 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2321153

Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR3R4, -OR3, -SR3, aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, -N(R6)-, -O-, -S-, -C(=O)- and alkylene; R1 and R2 are members independently selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, aryl, arylalkyl, -O-aryl, -S-aryl, -NO2, -NR7R8, -C(O)R9, -CO2R10, - C(O)NR7R8, -N(R7)C(O)R9, -N(R7)CO2R11, -N(R9)C(O)NR7R8, -S(O)mNR7R8, -S(O)nR9, -CN, halogen, and -N(R7)S(O)mR11.

L'invention concerne des composés et des compositions convenant au traitement d'infections virales, et en particulier, chez l'homme, l'infection par Cytomégalovirus. Ces composés contiennent les dérivés à base de pyrimidine de l'invention, représentés par la formule générale (I). Dans cette formule, X appartient au groupe des -NR?3¿R?4¿, -OR?3¿, -SR?3¿, aryle, alkyle et arylalkyle; Y appartient au group constitué d'une liaison covalente, des -N(R?6¿)-, -O-, -S-, -C(=O)-, et de l'alkylène; R?1¿ et R?2¿ appartiennent chacun indépendamment au groupe des hydrogène, alkyle, -O-alkyle, -S-alkyle, aryle, arylalkyle, -O-aryle, -S-aryle, -NO¿2?, -NR?7¿R?8¿, -C(O)R?9¿, -CO¿2?R?10¿, -C(O)NR?7¿R?8¿, -N(R?7¿)C(O)R?9¿, -N(R?7¿)CO¿2?R?11¿, -N(R?9¿)C(O)NR?7¿R?8¿, -S(O)¿m?NR?7¿R?8¿, -S(O)¿n?R?9¿, -CN, halogène, et -N(R?7¿)S(O)¿m?R?11¿.

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