Antineoplastic solution and method for treating neoplasms

A - Human Necessities – 61 – K

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A61K 31/17 (2006.01) A61K 31/00 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2055493

Disclosed are antineoplastic solutions for direct intratumoral delivery. The solutions are formulated using antineoplastic agents dissolved in organic, water miscible, solvent vehicles. The vehicle is selected such that a) the agent is dissolved in the vehicle, b) the agent is stable and bioavailable in the vehicle, and c) the vehicle readily diffuses through and permeates tumorous tissue. The solution is injected directly into the tumor and, as the vehicle permeates the tumor tissue it transports the agent therewith. In this way therapeutically effective levels of antineoplastic agent are effectively and rapidly delivered and disseminated into the tumor mass with little or no dissemination into surrounding healthy tissue.

L'invention concerne des solutions antinéoplastiques administrées par voie directe intratumorale. Les solutions se composent d'agents antinéoplastiques dissous dans des véhicules solvants organiques miscibles dans l'eau. Le véhicule est sélectionné de sorte que a) l'agent est dissous dans le véhicule, b) l'agent est stable et biodisponible dans le véhicule, et c) le véhicule se diffuse facilement et pénètre au travers des tissus de la tumeur. La solution est injectée directement dans la tumeur et, au fur et à mesure que le véhicule s'infiltre dans les tissus de la tumeur, il transporte avec lui l'agent. De cette manière, des niveaux thérapeutiquement efficaces d'agents antinéoplastiques sont administrés et disséminés efficacement et rapidement dans la masse de la tumeur, avec une dissémination faible voire nulle dans les tissus sains environnants.

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