C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 16/46 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2524771
The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using the transgenic animals of the invention to identify and/or evaluate compositions that can reduce the concentration of an agent, e.g., a biologic agent, in the serum, circulation and/or tissues of a subject are also provided.
La présente invention concerne, au moins en partie, des souris qui expriment un récepteur de complément de type 1 exogène (CR1) sur les érythrocytes. L'invention concerne aussi des structures génétiques codant pour les CR1 hétérologues à des fins d'expression sur les érythrocytes. L'invention concerne aussi des procédés d'utilisation d'animaux transgéniques de l'invention pour identifier et/ou évaluer les compositions qui peuvent réduire la concentration d'un agent tel qu'un agent biologique dans le sérum, la circulation et/ou les tissus d'un sujet.
Gowling Lafleur Henderson Llp
University Of Massachusetts
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