Novel scavenger receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 45/00 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2399865

Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper .beta.-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypo .alpha.-lipoproteinemia, transplantation, atherectomy, post angiogenic restenosis, bacterial infections; in the diagnostic, prophylactic and therapeutic methods thereof; and in the development of reagents and drugs for the same. The novel scavenger receptors include proteins comprising an amino acid sequence set out in SEQ ID NO: 2, 4 or 24 or proteins having equivalent properties to the same, or derivatives or fragments thereof as well as isolated polynucleotides comprising a nucleotide sequence encoding these proteins, and related molecules such as antibodies, antagonists and the like. Also disclosed are methods for the treatment using the same.

L'invention concerne de nouveaux récepteurs destructeurs possédant une structure SR et une structure du type collectine, ces structures étant des protéines possédant des séquences d'acide aminé (SEQ ID NO: 2, 4, et 24) ou des protéines ayant des propriétés comparables. Ces récepteurs destructeurs sont utilisés pour épurer les fonctions de macrophages et d'immunité de base, les mécanismes d'apparition de différentes maladies telles que l'artériosclérose, les complications diabétiques, la reconstriction consécutive à une angioplastie, et les infections bactériennes; pour diagnostiquer, prévenir, et traiter lesdites maladies, et développer des réactifs et des médicaments à partir de ceux-ci. L'invention concerne également des molécules associées audits récepteurs telles que des dérivés ou des fragments de ceux-ci, des séquences de base contenant des polynucléotides isolés codant lesdits récepteurs, des anticorps et des antagonistes. L'invention concerne enfin une technique de traitement utilisant ces récepteurs.

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