Multicatalytic protease inhibitors for use as anti-tumor agents

Details Multicatalytic protease inhibitors for use as anti-tumor agents Multicatalytic protease inhibitors for use as anti-tumor agents

A - Human Necessities

61

K

A61K 31/33 (2006.01) A61K 31/16 (2006.01) A61K 31/175 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/335 (2006.01) A61K 31/353 (2006.01) A61K 31/4035 (2006.01) A61K 31/69 (2006.01)

Patent

CA 2314259

The present invention relates to methods for the use of specified inhibitors of multicatalytic protease (MCP) for use as inducers of programmed cell death (i.e., apoptosis) in tumor cells, and more particularly as anti-tumor agents. The present invention provides methods for inducing apoptosis in transformed cells, inhibiting proliferation of transformed cells, and inhibiting the growth of tumors using the MCP inhibitors.

La présente invention concerne des procédés d'utilisation d'inhibiteurs spécifiques de protéase multicatalytique (MCP), utiles en tant qu'inducteurs de mort cellulaire programmée (c'est-à-dire l'apoptose) dans des cellules tumorales, et plus particulièrement en tant qu'agents antitumoraux. L'invention concerne également des procédés d'induction de l'apoptose dans des cellules transformées, l'inhibition de la prolifération de cellules transformées, ainsi que l'inhibition de la croissance de tumeurs, au moyen des inhibiteurs de la protéase multicatalytique.

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