Pharmaceutical composition for promoting angiogenesis

Details Pharmaceutical composition for promoting angiogenesis Pharmaceutical composition for promoting angiogenesis

A - Human Necessities

61

K

A61K 31/4468 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2553918

The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).

La présente invention propose une composition pharmaceutique favorisant l~angiogenèse, qui exerce une action favorisant l~angiogenèse même dans un système de culture vasculaire sans effet de microcirculation. Une composition pharmaceutique favorisant l~angiogenèse de la présente invention comprend au moins un composé sélectionné parmi un groupe comprenant un composé pipéridine représenté par la formule générale (1) ou les sels de celui-ci : (dans laquelle R représente un groupe benzoyle qui peut avoir, en tant que substituants sur le cycle phényle, de 1 à 3 groupes sélectionnés parmi un groupe comprenant un groupe amino, qui peut avoir un groupe alcanoyle inférieur, et un groupe alkyle inférieur ; R?1¿ représente un atome d~hydrogène ou un groupe alkyle inférieur ; et R?2¿ représente un groupe phénylalkyle inférieur).

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