Novel death associated proteins of the thap family and...

Details Novel death associated proteins of the thap family and... Novel death associated proteins of the thap family and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2471777

The invention relates to genes and proteins of the THAP (THanatos (death)- Associated Protein) family comprising a THAP domain, and their use in diagnostics, treatment of disease, and in the identification of molecules for the treatment of disease. The invention also relates to the Par4 protein and SLC chemokine pathways, including the interaction of Par4 and SLC with THAP family proteins, and the recruitment and localization of Par4 to PML nuclear bodies.

L'invention porte sur des gènes et sur des protéines de la famille de THAP (THanatos (death)-Associated Protein) (protéine associée à la mort) comprenant un domaine THAP, et sur l'utilisation de ces gènes et protéines dans des diagnostics, traitements et maladies, et dans l'identification de molécules dans le traitement d'une maladie. L'invention porte également sur les mécanismes d'action de la protéine Par4 et la chimiokine SLC tels que l'interaction de Par4 et SLC avec les protéines de la famille de THAP, et le recrutement et la localisation de Par4 sur les corps nucléaires PML.

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