Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 215/48 (2006.01) C07D 243/08 (2006.01) C07D 295/13 (2006.01) C07D 295/192 (2006.01) C07D 307/79 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2165176

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compound of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

L'invention concerne des composés inhibiteurs de farnésyle-protéine transférase (Ftase) et la farnésylation de la protéine d'oncogène Ras. L'invention concerne en outre des compositions chimiothérapiques contenant les composés de l'invention, des procédés d'inhibition de farnesyle-protéine transférase et la farnésylation de la protéine d'oncogène Ras.

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