C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441832
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
L'invention concerne des polypeptides sécrétés humains, ainsi que des molécules d'acides nucléiques isolés codant lesdits polypeptides, servant à diagnostiquer et à traiter des maladies et des affections auto-immunes. L'invention concerne également des anticorps qui fixent ces polypeptides, ainsi que des vecteurs, des cellules hôtes, des méthodes de recombinaison et de synthèse pour produire lesdits polynucléotides, polypeptides et/ou anticorps. L'invention concerne en outre des méthodes de criblage servant à identifier des agonistes et des antagonistes des polynucléotides et polypeptides de l'invention. Elle concerne enfin des méthodes et des compositions servant à inhiber ou stimuler la production et la fonction des polypeptides de l'invention.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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