C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2498523
Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.
L'invention concerne des anticorps scFv mono- et multivalents comprenant les sites de liaison spécifiques pour le marqueur des lymphocytes T CD3 humain. Ces anticorps sont fortement immunosuppressifs et ne provoquent pas une libération importante de cytokines. Cette invention concerne également des polynucléotides codant pour ces anticorps ainsi que des vecteurs contenant ces polynucléotides, des cellules hôtes transformées avec ces derniers et leur utilisation dans la production de ces anticorps. Des compositions pharmaceutiques contenant l'un des polypeptides, anticorps ou vecteurs susmentionnés peuvent être utilisées en immunothérapie, de préférence contre des rejets aigus de greffe.
Kipriyanov Sergey
Le Gall Fabrice
Little Melvin
Reusch Uwe
Affimed Therapeutics Ag
Gowling Lafleur Henderson Llp
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