Pyrazinoylguanidine compounds useful in the treatment of...

Details Pyrazinoylguanidine compounds useful in the treatment of... Pyrazinoylguanidine compounds useful in the treatment of...

C - Chemistry, Metallurgy

07

D

C07D 241/26 (2006.01) A61K 31/497 (2006.01) A61P 11/12 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2631347

A compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M1, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions mediated by the blockade of an epithelial sodium channel, particularly an inflammatory or allergic condition.

La présente invention concerne un composé de formule (I) ou des tautomère, ou stéréoisomères, ou solvates ou des sels pharmaceutiquement acceptables de ceux-ci, dans laquelle: M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 et R5a sont tels que définis dans la description pour le traitement de conditions liées au blocage du canal sodique épithélial, notamment une pathologie inflammatoire ou allergique.

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