Method of enhancing neural stem cell proliferation,...

Details Method of enhancing neural stem cell proliferation,... Method of enhancing neural stem cell proliferation,...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 35/12 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2492442

The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating polypeptide (PACAP). In a preferred embodiment, additional growth factors are also utilized. The present invention can be practiced in vivo and in vitro, rendering it useful for the treatment of neurodegenerative disease and other neural trauma.

L'invention concerne un procédé d'augmentation du nombre et/ou de la différentiation de cellules souches neurales et/ou d'amélioration de la descendance de cellule souche neurale au moyen du polypeptide d'activation d'adénylate cyclase hypophysaire (PACAP). Dans un mode préféré de réalisation, on utilise aussi des facteurs de croissance supplémentaires. Il est possible de pratiquer le procédé de l'invention <i>in vivo</i> et <i>in vitro</i>, ce qui le rend utile dans le traitement de maladie neurodégénérative et dans d'autres lésions nerveuses.

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