C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/04 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) C07D 217/16 (2006.01) C07D 217/24 (2006.01) C07D 311/76 (2006.01) C07D 335/04 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2424292
Substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2 (COX-2) and/or interleukin-10 (IL-10). Compositions containing such compounds and methods of using such compounds for treatment and/or prevention of inflammation, inflammatory diseases, immunologic diseases and other diseases mediated by TNF- alpha, IL-6, COX-2 and/or IL-10 are also disclosed.
L'invention concerne des isoquinoléines, des isochromanones et des isothiochromanones substituées inhibant des cytokines pro-inflammatoires telles que le facteur de nécrose tumorale alpha (TNF-alpha), l'interleukine 6 (IL-6), l'enzyme cyclooxygénase 2 (COX-2) et/ou l'interleukine 10 (IL-10). L'invention concerne également des compositions renfermant ces composés ainsi que des méthodes d'utilisation desdits composés dans le traitement et/ou la prévention de l'inflammation, de maladies inflammatoires, de maladies immunologiques et d'autres maladies induites par TNF-alpha, IL-6, COX-2 et/ou IL-10.
Dey Debendranath
Nag Bishwajit
Neogi Partha
Sen Ananda
Sharma Somesh D.
Calyx Therapeutics Inc.
Gowan Intellectual Property
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