Non-aqueous colonic purgative formulations

Details Non-aqueous colonic purgative formulations Non-aqueous colonic purgative formulations

A - Human Necessities

61

K

A61K 47/02 (2006.01) A61K 33/42 (2006.01)

Patent

CA 2241445

Orally administered colonic purgative formulations and methods of its use for effecting partial or complete purgation of the colon in mammals, the formulations consisting of non-aqueous admixtures of monobasic, dibasic and tribasic sodium phosphates administered in table or capsule form in concentrations of from .01 to .85 grams per kilogram body weight. Preferred embodiments include the addition of binders, dispersants and buffers which do not adversely affect osmolality or effectiveness of the purgative formulations.

L'invention porte sur des préparations purgatives pour le côlon, à administration orale, et sur leur mode d'utilisation en vue de l'obtention d'un effet purgatif partiel ou total du côlon chez les mammifères. Ladite préparation consiste en mélanges non aqueux de phosphates de sodium, monobasique, dibasique et tribasique, s'administrant sous forme de comprimés ou de gélules à des concentrations allant de 0,01 à 0,85 g par kg de poids du corps. Les réalisations préférées comportent l'adjonction de liants, de dispersants et de tampons sans effets adverses sur l'osmolalité ou l'efficacité des préparations.

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