C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 38/04 (2006.01) A61P 9/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2449292
Compounds of formula (I) wherein R, R1, COOR2, R3-R7, alk, and X have meaning as defined, such being useful as dual inhibitors of angiotensin converting enzyme and neutral endopeptidase, as well as inhibitors of endothelin converting enzyme. In a preferred embodiment, R and R5 represent hydrogen; R1 represents benzyl; R3 represents hydrogen, acetyl or methoxyacetyl; R4 represents isopropyl or tert-butyl; R6 and R7 represent methyl; X represents - O-; alk represents methylene; and COOR2 represents carboxyl or ethoxycarbonyl.
L'invention concerne les composés de la formule (I) dans laquelle R, R¿1?, COOR¿2?, R¿3?-R¿7?, et X ont la signification donnée dans le descriptif. Les composés selon l'invention servent d'inhibiteurs doubles de l'enzyme de conversion de l'angiotensine et de l'endopeptidase neutre, ainsi que d'inhibiteurs de l'enzyme de conversion de l'endothéline.
Fetherstonhaugh & Co.
Novartis Ag
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