Human circulating virus-inhibiting peptide (virip) and its use

Details Human circulating virus-inhibiting peptide (virip) and its use Human circulating virus-inhibiting peptide (virip) and its use

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 1/04 (2006.01) C07K 1/14 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 16/40 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2390652

A peptide having the following amino acid sequence: Z1-LEAIPMSIPPEVKFNKPFVF-Z2 (VIRIP) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, polyethylene glycol (PEG) modified, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of VIRIP; wherein Z1 and Z2 are independently a sequence of from 0 to 10 amino acid residues, and if Z1 or Z2 = zero amino acid residues, then Z1 = H and/or Z2 = COOH.

L'invention concerne un peptide ayant la séquence d'acides aminés suivante: Z¿1?-LEAIPMSIPPEVKFNKPFVF-Z¿2? (VIRIP) ainsi que ses fragments et/ou variantes et/ou dérivés biologiquement actifs, notamment des dérivés amidifiés, acétylés, sulfatés, modifiés par polyéthylèneglycol (PEG), phosphorylés et/ou glycosylés et enfin les peptides pouvant préparés par une synthèse multiple et ayant l'activité biologique du VIRIP, où Z¿1?, Z¿2? représentent indépendamment 0 à 10 restes d'acides aminés et si Z ou Z¿2?=0 acide aminé, alors Z¿1?=H et/ou Z¿2?=COOH.

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