Therapeutically useful synthetic oligonucleotides

Details Therapeutically useful synthetic oligonucleotides Therapeutically useful synthetic oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2393808

The present invention provides a composition and method comprising a 2-20 base 3'-OH, 5'-OH synthetic oligonucleotide (sequence) selected from the group consisting of (GxTy)n, (TyGx)n, a(GxTy)n, a(TyGx)n, (GxTy)nb, (TyGx)nb, a(GxTy)nb, a(TyGx)nb, wherein x and y is an integer between 1 and 7, n is an integer between 1 and 12, a and b are one or more As, Cs, Gs or Ts and wherein the sequence induces a response selected from the group consisting of induction of cell cycle arrest, inhibition of proliferation, activation of caspases and induction of apoptosis in cancer cells and production of cytokines by immune system cells.

L'invention concerne une composition et une méthode comprenant une séquence d'oligonucléotides synthétiques ou un oligonucléotide 3'-OH, 5'-OH comprenant entre 2 et 20 bases choisis dans le groupe constitué de (G¿x?T¿y?)¿n?, (T¿y?G¿x?)¿n?, a(G¿x?T¿y?)¿n?, a(T¿y?G¿x?)¿n?, (G¿x?T¿y?)¿n?b, (T¿y?G¿x?)¿n?b, a(G¿x?T¿y?)¿n?b, a(T¿y?G¿x?)¿n?b, où x et y représentent un entier compris entre 1 et 7, n représente un entier compris entre 1 et 12, a et b représentent un ou plusieurs As, Cs, Gs ou Ts et où la séquence induit une des réponses suivantes : induction de l'arrêt du cycle cellulaire, inhibition de la prolifération, activation de caspases et induction de l'apoptose sur les cellules cancéreuses et production de cytokines par des cellules du système immunitaire.

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