Methods for regulating trka expression

Details Methods for regulating trka expression Methods for regulating trka expression

A - Human Necessities

01

N

A01N 43/12 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01)

Patent

CA 2304114

The current invention provides methods for the upregulation of trkA in a mammal, including humans, comprising the administration of an effective amount of a compound of formula (I), wherein R1 and R3 are, independently, -H, -CH3, - CO(C1-C6 alkyl), or -COAr, where Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, piperidine, and hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof. In addition, the current invention provides method to increase the effect of NGF (Nerve Growth Factor), whether the NGF is from endogenous of exogenous sources. Further, the current invention provides methods for maintaining the homeostasis and health of the hippocampus, hypothalamus, and cortex, thus maintaining their biological functions.

La présente invention concerne des procédés de régulation positive du trkA chez un mammifère, y compris un être humain, lesquels procédés consistent à administrer une quantité efficace d'un composé répondant à la formule (I): dans laquelle R?1¿ et R?3¿ sont, indépendamment, -H, -CH¿3?, -CO(C¿1?-C¿6? alkyle), ou -COAr, dans laquelle Ar est un phényle facultativement substitué; R?2¿ est choisi dans le groupe composé de la pyrrolidine, de la pipéridine et de l'hexaméthylèneimine; ou est un sel ou un solvant pharmaceutiquement acceptable de ces derniers. En outre, la présente invention concerne un procédé permettant d'augmenter l'effet du FCN (facteur de croissance du tissu nerveux), que ce dernier provienne de sources endogènes ou exogènes. L'invention se rapporte également à des procédés permettant de préserver l'homéostasie et la santé de l'hippocampe, de l'hypothalamus et du cortex et, par conséquent, de maintenir leurs fonctions biologiques.

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