G - Physics – 21 – G
Patent
G - Physics
21
G
G21G 4/04 (2006.01) A61K 51/10 (2006.01)
Patent
CA 2304521
This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunoconjugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule (5) containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container (20) provided with radiation panels (21); b) a dissolving medium is poured into the ampoule (5); c) the solution obtained in the ampoule is transferred into an ion exchange column (6); d) an elution medium is circulated through the column (6); e) the eluate containing eluted Bi-213 is pumped towards a vial (10) for quantification and quality control.
Cette invention concerne un procédé et un dispositif de préparation de Bi-213 à intégrer dans un radio-immunoconjugué destiné à un usage thérapeutique humain. Selon l'invention, ce procédé comprend la suite d'étapes consistant: a) à charger une ampoule (5), contenant de l'actinium-225 dépourvu de colloïde et obtenu à partir du séchage d'une solution de nitrate d'actinium, dans un contenant (20) doté de panneaux de rayonnement (21); b) à verser un milieu de dissolution dans l'ampoule (5); c) à transférer la solution obtenue dans l'ampoule, dans une colonne échangeuse d'ions (6); d) à faire circuler un milieu d'élution à travers la colonne (6), et e) à pomper l'éluat contenant Bi-213 élué vers un flacon (10) aux fins de quantification et de contrôle de qualité.
Apostolidis Christos
Brandalise Bruno
Janssens Willem
Koch Lothar
Molinet Roger
European Community (ec)
Robic
LandOfFree
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