A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 38/06 (2006.01)
Patent
CA 2732777
The present invention provides pharmaceutical formulations of an HCV protease inhibitor in a solid dispersion with an excipient which provided advantageous pharmacokinetic properties for inhibiting or treating HCV infection. In preferred embodiments, the excipient is at least one polymer. The present invention also provides processes for manufacturing such formulations as well as uses of said composition for the manufacture of a medicament for treating or ameliorating one or more symptoms of HCV or disorders associated with HCV in a subject in need thereof using said formulations.
La présente invention concerne des formulations pharmaceutiques dun inhibiteur de protéase de VHC dans une dispersion solide comprenant un excipient présentant des propriétés pharmacocinétiques avantageuses pour inhiber ou traiter linfection par le VHC. Dans des modes de réalisation préférés, lexcipient est au moins un polymère. La présente invention concerne en outre des procédés pour fabriquer de telles formulations ainsi que des procédés pour traiter ou améliorer un ou plusieurs symptômes du VHC ou des troubles associés au VHC chez un sujet en ayant besoin en utilisant lesdites formulations.
Hu Chengjiu
Omelczuk Marcelo Osvaldo
Sheth Ashlesh
Yue Baohua
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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