Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/06 (2006.01)

Patent

CA 2587800

The present invention is directed to novel substituted fused aminopipeiridines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (~DPP-IV inhibitors~) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

L'invention concerne de nouvelles aminopipéridines fusionnées substituées représentées par la formule (I) qui sont des inhibiteurs de la dipeptidyle peptidase-IV (inhibiteurs DPP-IV) et qui sont utilisées pour traiter ou prévenir des maladies impliquant la dipeptidyle peptidase-IV, telles que le diabète et plus particulièrement le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés et de ces compositions pour prévenir ou traiter des maladies impliquant la dipeptidyle peptidase-IV.

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