Vascular adhesion molecules and modulation of their function

Details Vascular adhesion molecules and modulation of their function Vascular adhesion molecules and modulation of their function

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61P 9/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2362896

The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70 % sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 or 2 (CRAM-1 or CRAM-2) as depicted in the Figure upper and second row, respectively, and antibodies thereto as well as their use in treatment of inflammation and tumors.

L'invention concerne un nouveau polypeptide sous forme isolée appartenant à une sous-famille de la superfamille des immunoglobines humaines, lequel polypeptide présente au moins 70 % d'homologie de séquence avec la séquences d'acides aminé des molécules 1 ou 2 d'adhésion régulée par confluence murines (CRAM-1 ou CRAM-2) telles qu'illustrées dans la figure seconde rangée supérieure, respectivement, et leurs anticorps ainsi que leur utilisation dans le traitement de l'inflammation et des tumeurs.

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