Nitrate esters of aminoalcohols

Details Nitrate esters of aminoalcohols Nitrate esters of aminoalcohols

C - Chemistry, Metallurgy

07

C

C07C 233/13 (2006.01) A61K 31/343 (2006.01) A61K 31/404 (2006.01) A61K 31/416 (2006.01) A61K 31/44 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07D 209/08 (2006.01) C07D 213/64 (2006.01) C07D 231/56 (2006.01) C07D 265/36 (2006.01) C07D 307/80 (2006.01)

Patent

CA 2663129

The application relates to novel nitrate ester derivatives of substituted aminoalcohols of the general formula (I), wherein R1, R2, R3, V, X, Y and Z0 have the meanings explained in more detail in the description, to a process for their preparation and to the use of these compounds as therapeutics in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage accompanying high blood pressure.

L'invention concerne de nouveaux dérivés d'esters de l'acide nitrique d'amino-alcool substitués représentés par la formule générale (I), dans laquelle R1, R2, R3, V, X, Y et Z0 présentent les significations expliquées de façon plus détaillée dans la description. L'invention concerne également un procédé de préparation desdits dérivés ainsi que l'utilisation desdits composés en tant qu'agents thérapeutiques dans des maladies cardiovasculaires, en particulier lors d'une pression sanguine élevée et lors d'une lésion vasculaire et d'organe accompagnant une pression sanguine élevée.

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