Substituted 2,4-diaminopyrimidines

Details Substituted 2,4-diaminopyrimidines Substituted 2,4-diaminopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/506 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2281642

The invention is concerned with compounds of general formula (I), wherein R1 signifies lower-alkoxy, R2 signifies hydroxy or lower-alkoxy, R3 signifies hydrogen, cyano, alkyl, alkenyl, cycloalkyl, aryl, heterocycyl, aralkyl, aryl-Q-alkyl, heterocyclalkyl or a group of the formula -(CH2)n-, Q signifies -SO-; R4, R?4'? each independently signify hydrogen, alkyl, aryl or heterocyclalkyl, R5 signifies hydrogen, alkyl, alkoxy, aryl or heterocycyl, or R4 and R5 together can form a group -(CH2)n-, and n is a whole number of 2 to 5, as well as pharmaceutically usable salts thereof; the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable salts and intermediates for their manufacture.

L'invention a pour objet les composés selon la formule générale (I), dans laquelle R<1> représente alcoxy inférieur, R<2> représente hydroxy ou alcoxy inférieur, R<3> signifie hydrogène, cyano, alkyle, alkényle, cycloalkyle, aryle, hétérocycyle, aralkyle, aryl-Q-alkyle, hétérocyclalkyle ou un groupe de la formule -(CH2)n-, Q signifie -SO-; R<4>, R<4'> représentent chacun indépendamment hydrogène, alkyle, aryle ou hétérocyclyalkyle; R<5> représente hydrogène, alkyle, aryle ou hétérocycyle, ou R<4> et R<5> ensemble peuvent former un groupe -(CH2)n- et n est un nombre entier compris entre 2 et 5. L'invention traite aussi de sels pharmaceutiquement acceptables de ces derniers. L'invention concerne également l'utilisation de ces composés et leurs sels comme substances thérapeutiquement actives; des médicaments à base de ces substances et leur production; l'utilisation de ces substances comme médicaments et pour la production de médicaments actifs contre les bactéries. L'invention traite aussi de la fabrication des composés selon la formule (I) et de leurs sels pharmaceutiquement acceptables et des produits intermédiaires pour leur fabrication.

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