C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2268034
The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.
La présente invention concerne un procédé de traitement d'un organisme souffrant d'une maladie ou d'un état caractérisé par une anomalie se produisant dans le mécanisme de transduction d'un signal, lequel mécanisme de transduction comprend une protéine rdgB. L'invention concerne également des procédés de diagnostic de telles maladies, ainsi que des procédés destinés au criblage d'agents utiles dans le traitement de telles maladies. L'invention concerne encore un acide nucléique purifié et/ou isolé, codant une protéine rdgB.
Lev Sima
Plowman Gregory D.
Schlessinger Joseph
New York University Medical Center
Smart & Biggar
Sugen Inc.
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