Immunotherapeutic compositions and methods for the treatment...

A - Human Necessities – 61 – K

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A61K 35/12 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 2497554

Provided are immunotherapeutic compositions and methods for the treatment of cancers characterized by the presence of moderately to well-differentiated cancer cells. Exemplary immunotherapeutic compositions employ antigen presenting cells, including dendritic cells, activated by a protein conjugate such as fusion proteins including a prostatic acid phosphatase/granulocyte- macrophage colony stimulation factor fusion protein. Also disclosed are methods for assessing the susceptibility of cancer cells to treatment regimens employing one or more immunotherapeutic composition.

La présente invention concerne des compositions immunothérapeutiques et des méthodes permettant de traiter des cancers qui se caractérisent par la présence de cellules cancéreuses modérément à bien différenciées. Des compositions immunothérapeutiques exemplaires utilisent des cellules des présentation de l'antigène, y compris des cellules dendritiques, activées par un conjugué protéique, tel que des protéines hybrides, parmi lesquelles une protéine hybride du facteur de stimulation des colonies granulocyte-macrophage/phosphatase acide prostatique. Cette invention concerne également des méthodes permettant d'évaluer la sensibilité des cellules cancéreuses à des schémas thérapeutiques utilisant un ou plusieurs compositions immunothérapeutiques.

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