Nucleic acids encoding interferon gamma inducing factor-2

Details Nucleic acids encoding interferon gamma inducing factor-2 Nucleic acids encoding interferon gamma inducing factor-2

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2238885

The present invention provides a polynucleotide (igif-2) which identifies and encodes a novel interferon gamma inducing factor-2 (IGIF-2) which was expressed in adenoid, brain, kidney, liver, lung, skin, synovium, and T- lymphocytes. The present invention also provides for antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified IGIF-2; antibodies, antagonists and inhibitors; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as therapeutic for immuno- compromised individuals and as a positive control in diagnostic assays for the detection of aberrant IGIF-2 expression or altered leukocyte or lymphocyte activity.

La présente invention concerne un polynucléotide (igif-2) qui identifie et code un nouveau facteur 2 inducteur de l'interféron gamma (IGIF-2) exprimé dans l'adénoïde, le cerveau, le rein, le foie, le poumon, la peau, la synovie, et les lymphocytes T. La présente invention concerne également des molécules antisens. Elle concerne en outre des vecteurs d'expression obtenus par génie génétique et des cellules hôtes pour la production de IGIF-2 purifié. Elle concerne aussi des anticorps, antagonistes et inhibiteurs, ainsi que des compositions pharmaceutiques et des méthodes de traitement à base de ce polypeptide, ses anticorps, antagonistes et inhibiteurs. L'invention concerne spécifiquement l'utilisation de ce polypeptide, en tant que substance thérapeutique pour des individus immuno-affaiblis, et en tant que contrôle positif de méthodes de diagnostic pour la détection de l'expression aberrante de IGIF-2, ou d'altérations de l'activité de leucocytes ou de lymphocytes.

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