A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/14 (2006.01) A61F 2/02 (2006.01) C12M 3/06 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2173594
A novel cell seeded hollow fiber bioreactor is described as a potential bioartifical kidney. Renal cells are seeded along a hollow fiber (10) in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure as well as studying renal tubululogenesis in vitro.
Un nouveau bioréacteur à fibres creuses ensemencées de cellules constitue un rein bioartificiel potentiel. Des cellules rénales sont ensemencées le long d'une fibre creuse dans un bioréacteur à perfusion pour reproduire les fonctions d'ultrafiltration et de transport propres au rein. La persistance des fonctions et de l'ultrastructure spécifiques aux tissus en cause indique que ce bioréacteur constitue un dispositif économique pour traiter les défaillances rénales et étudier in vitro la tubulogenèse rénale.
Cieslinski Deborah A.
Humes H. David
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Regents Of The University Of Michigan
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