Porous synthetic bone graft and method of manufacture thereof

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/12 (2006.01) A61F 2/28 (2006.01) A61F 2/46 (2006.01) C04B 38/02 (2006.01) C04B 38/06 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01) A61F 2/30 (2006.01)

Patent

CA 2417895

Synthetic bone for grafts avoid the necessity of autograft. Commercially available synthetic bone grafts have inconsistent pore size and may fail to enable osteoingrowth. The present invention permits controllable pore size, shape and pore orientation enabling improved bone replacement. A process for preparing artificial bone is described which comprises: (i) preparing a mixture of a finely divided bio-compatible ceramic powder, an organic binder and a pore-forming agent in an inert liquid to form a body and causing at least some of the pore-forming agent to align along a common axis; (ii) optionally shaping the resulting body; (iii) allowing the pore-forming agent to form a porous structure in the body; (iv) heating the shaped body to a temperature sufficient to fix the porous structure and; (v) further heating the body to eliminate residues of organic binder and pore- forming agent and to fuse it.

L'invention concerne un procédé de préparation d'os artificiel, qui consiste à: (i) préparer un mélange d'une poudre céramique biocompatible finement fractionnée, d'un liant organique et d'un générateur de pores dans un liquide inerte pour former un corps et amener au moins une partie du générateur de pores à s'aligner suivant un axe commun; (ii) donner éventuellement une forme au corps résultant; (iii) permettre au générateur de pores de former, dans le corps, une structure poreuse; (iv) chauffer le corps ainsi formé à une température suffisante pour fixer la structure poreuse et (v) poursuivre le chauffage du corps pour évacuer les résidus du liant organique et du générateur de pores et le faire fondre.

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