Multiblock biodegradable hydrogels for use as controlled...

Details Multiblock biodegradable hydrogels for use as controlled... Multiblock biodegradable hydrogels for use as controlled...

C - Chemistry, Metallurgy

08

G

C08G 81/00 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 9/20 (2006.01) A61K 9/51 (2006.01) A61K 47/32 (2006.01) A61L 15/58 (2006.01) A61L 15/60 (2006.01) C08G 63/00 (2006.01) C08G 63/91 (2006.01) C08G 65/32 (2006.01) C08G 65/329 (2006.01) C08J 3/075 (2006.01) C08L 71/02 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2228118

Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a cross-linkable group are provided. The macromers can be covalently cross-linked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.

Macromères gélifiants comprenant au moins quatre blocs polymères, deux d'entre eux au moins étant hydrophobes et l'un d'entre eux au moins étant hydrophile, et comportant un groupe pouvant subir une réticulation. Ces macromères peuvent subir une réticulation covalente permettant de former un gel sur un tissu in vivo. Les gels obtenus à partir des macromères possèdent plusieurs propriétés: ils sont notamment thermosensibles et lipophiles. Ils peuvent être utilisés dans diverses applications médicales, dont l'administration de médicaments et le revêtement de tissus.

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