Inorganic nanoparticles, preparation and uses thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2727576

The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X--Rays, .gamma.-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.

La présente invention concerne de nouvelles particules excitables pouvant être utilisées dans le domaine de la santé. Elle concerne plus particulièrement des particules pouvant générer des électrons et/ou un photon à haute énergie lorsqu'elles sont excitées par des rayonnements ionisants tels que le rayons X, les rayons gamma, un isotope radioactif et/ou des faisceaux électroniques. Elle concerne les utilisations de ces particules dans le domaine de la santé, notamment de la santé humaine. Les particules de l'invention sont constituées d'une matière inorganique contenant de l'oxygène, en particulier un oxyde, ladite matière présentant une densité appropriée et pouvant être activée in vitro, ex vivo ou in vivo par excitation externe réglable, en vue de perturber, de modifier ou de détruire des cellules cibles, des tissus ou des organes. L'invention concerne en outre des méthodes de production desdites particules, et des compositions pharmaceutiques ou pour dispositifs médicaux contenant ces particules.

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