Polymorphic and amorphous forms of...

Details Polymorphic and amorphous forms of... Polymorphic and amorphous forms of...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01)

Patent

CA 2559639

The invention provides several polymorphic forms and an amorphous form of 2,5- ~Dimethyl-2H-pyrazole-3-carboxylic acid {2-fluoro-5-[3-((E)-2-pyridin-2-yl- vinyl)-1H-indazol-6~ylamino]-phenyl}-amide, pharmaceutical compositions containing such polymorphic or amorphous forms, and methods of using such pharmaceutical compositions to treat disease states mediated by protein kinases, such as cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation.

L'invention concerne plusieurs formes polymorphes et une forme amorphe de 2,5-diméthyle-2H-pyrazole-3-acide carboxylique {2-fluoro-5-[3-((E)-2-pyridine-2-yle-vinyle)-1H-indazole-6-ylamino]-phényle}-amide, des compositions pharmaceutiques contenant ces formes polymorphes ou amorphes, et des méthodes d'utilisation de ces compositions pharmaceutiques pour traiter des maladies dues à des protéines kinases telles que le cancer, et d'autres états pathologiques associés à l'angiogénèse et/ou à la prolifération cellulaire indésirables.

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