New derivatives of neuraminic acid

Details New derivatives of neuraminic acid New derivatives of neuraminic acid

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) C07H 13/02 (2006.01) C07H 13/04 (2006.01) C07H 13/06 (2006.01) C07H 13/08 (2006.01) C07H 13/10 (2006.01) C07H 15/04 (2006.01) C07J 17/00 (2006.01) C07K 5/04 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2141679

Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an aryl residue of an aliphatic, araliphatic aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their peracylated derivatives at the hydroxy groups of both these series of amides. These compounds are therapeutically useful in providing a protective effect against the neurotoxicity induced by excitatory amino acids, and can therefore be used in therapies of the central nervous system following cerebral degenerations or lesions, metabolic dysfunctions, aging, and toxic-infective and chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases.

L'invention se rapporte à de nouveaux dérivés de l'acide neuraminique de la formule (I) dans laquelle Ac représente un résidu acyle d'un acide aliphatique, araliphatique aromatique, alicyclique ou carboxylique hétérocyclique renfermant des amides carboxyliques, leurs glycosides 2-hydrocarbyle, et leurs dérivés peracylés au niveau des groupes hydroxy des deux séries d'amides. Ces composés sont thérapeutiquement utiles pour obtenir un effet protecteur de la neurotoxicité induite par des acides aminés excitateurs, et peuvent, par conséquent, être utilisés dans des thérapies du système nerveux central suite à des lésions ou dégénérescences cérébrales, à des dysfonctionnements métaboliques, au vieillissement, à des maladies toxi-infectieuses neurodégénératives chroniques telles que les maladies d'Alzheimer, de Parkinson et d'Huntington.

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