Phenyl substituted carboxylic acids as inhibitors of protein...

Details Phenyl substituted carboxylic acids as inhibitors of protein... Phenyl substituted carboxylic acids as inhibitors of protein...

C - Chemistry, Metallurgy

07

D

C07D 307/81 (2006.01) A61K 31/343 (2006.01) A61P 3/10 (2006.01) C07C 307/00 (2006.01) C07D 209/08 (2006.01) C07D 307/79 (2006.01) C07D 307/80 (2006.01) C07D 307/91 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2524235

Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

La présente invention concerne des composés et des sels pharmaceutiquement acceptables de formule (A), utiles dans le traitement de troubles métaboliques liés à la résistance à l'insuline, à la résistance à la leptine, ou à l'hyperglycémie. Des composés de l'invention incluent des inhibiteurs des protéine-tyrosine phosphatases, en particulier la protéine-tyrosine phosphatase 1B (PTP-1B), qui sont utiles dans le traitement du diabète et autres maladies induites par PTP, telles que le cancer, les maladies neurodégénératives et analogues. L'invention concerne en outre des compositions pharmaceutiques contenant ces composés et des méthodes de traitement desdites affections avec les composés de l'invention.

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