Il-6 mutein

Details Il-6 mutein Il-6 mutein

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2251355

The present invention relates to a new IL-6 mutein, a DNA sequence coding for it, its use in therapy as well as a pharmaceutical composition comprising it. It is a potent IL-6 antagonist and can be advantageously used as a medicament in the treatment of diseases in which IL-6 has a pathogenetic action, such as, for example, plasmocytoma/myeloma, osteoporosis and neoplastic and autoimmune diseases.

Nouvelle mutéine de IL-6, séquence d'ADN la codant, son utilisation en thérapie, ainsi que composition pharmaceutique la renfermant. Cette nouvelle mutéine est un antagoniste puissant de IL-6 et peut être avantageusement utilisée en tant que médicament dans le traitement de maladies dans lesquelles IL-6 possède une action pathogène, telles que le plasmocytome/myélome, l'ostéoporose et les maladies néoplasiques et auto-immunes, par exemple.

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