A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/28 (2006.01) A61K 31/555 (2006.01)
Patent
CA 2318159
Novel spermicidal compounds which are organometallic cyclopentadienyl metal complexes, particularly vanadium (IV) complexes, are described including corresponding contraceptive and therapeutic compositions and method for providing contraception and selective killing of testicular germ cells. Included among the vanadium complexes are vanadocene dichloride, vanadocene dibromide, bis(methylcyclopentadienyl)vanadium dichloride, vanadocene diiodide, vanadocene dipseudohalides, and others. Most active found was vanadocene diselenocyanate.
La présente invention concerne de nouveaux composés spermicide qui sont des complexes métalliques de cyclopentadienyl organométallique, notamment des complexes de vanadium (IV), comprenant des compositions contraceptives et thérapeutiques correspondantes et le procédé pour assurer la contraception et l'élimination sélective des cellules des germes de testicules. Parmi les complexes de vanadium figurent le dichlorure de vanadocene, le dibromure de vanadocene, le dichlorure de bis(methylcyclopentdienyle) de vanadium, le diiodure de vanadocene, les di-pseudohalogenures de vanadocene, et d'autres. Le diselenocyanate de vanadocene s'est prouvé le plus actif.
D'cruz Osmond
Ghosh Phalguni
Uckun Fatih M.
Goudreau Gage Dubuc
Parker Hughes Institute
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