Carrier for targeting nerve cells

Details Carrier for targeting nerve cells Carrier for targeting nerve cells

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) A61K 8/64 (2006.01) A61K 8/66 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) C07K 14/195 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/50 (2006.01) C12N 9/52 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01)

Patent

CA 2606030

The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.

L'invention concerne une protéine de transport, obtenue par modification d'une chaîne lourde de neurotoxine comprenant du Clostridium botulinum, (i) la protéine se liant à des cellules nerveuses avec une affinité supérieure ou inférieure à la neurotoxine d'origine ; (ii) la protéine présente neurotoxicité supérieure ou inférieure à la neurotoxine d'origine ; de préférence, la neurotoxicité est déterminée dans l'essai biologique de l'hémidiaphragme ; et/ou (iii) la protéine présente une affinité inférieure, par rapport à la neurotoxine d'origine, avec les anticorps à neutraliser. L'invention concerne également un procédé de production et d'utilisation de ladite protéine dans des compositions pharmaceutiques et cosmétiques.

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