Antidepressant-3-halophenylpiperazinyl-propyl derivatives of...

Details Antidepressant-3-halophenylpiperazinyl-propyl derivatives of... Antidepressant-3-halophenylpiperazinyl-propyl derivatives of...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) C07D 249/12 (2006.01)

Patent

CA 2094890

2-(3-[4-(3-Halophenyl)-1-piperazinyl]propyl derivatives of certain 4-alkyl-or 4-phenoxyalkyl-2,4-dihydro-3H-1,2,4- triazol-3-ones and triazol-3,5-diones are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology. Compounds of Formula I and their acid addition salts and/or hydrates are disclosed: (see formula I) In the foregoing structural formula the symbol R denotes halogen, preferably chloro, or trifluoromethyl; Z is hydrogen or (see formula II) with R1 being hydrogen, halogen, C1-4 alkoxy and trifluoromethyl; and n is an integer from 2-4. The symbol X is either an oxygen atom, providing a carbonyl moiety; or is an acetyl group The single and dotted lines represent either a covalent single bond or a double bond. The compounds of Formula I exist then in two structural subclasses, Ia and Ib.

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