Imidazonaphthyridine derivatives

Details Imidazonaphthyridine derivatives Imidazonaphthyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2043715

Disclosed are imidazonaphthyridine derivatives represented by formula (I) Image (I) wherein: R1 represents lower alkyl or substituted or unsubsti- tuted aryl; and X-Y-Z represents Image or Image wherein R2 represents hydrogen, lower alkyl, alkeny1, aralkeny1, or -C(R5)H-(CH2)n-R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable salts thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

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