Oral formulation comprising an inhibitor compound of the...

Details Oral formulation comprising an inhibitor compound of the... Oral formulation comprising an inhibitor compound of the...

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 45/06 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2425831

An oral pharmaceutical formulation comprising an inhibitor compound of the ileal bile acid transport (IBAT inhibitor), an HMG Co-A reductase inhibitor and a therapeutically acceptable carrier characterised in that the formulation is designed to deliver the IBAT inhibitor in the ileum and the HBG Co A reducetase inhibitor non-specifically into the GI tract. The IBAT inhibitor compound and the HMG Co-A reductase inhibitor can also be administered in combination with a bile acid binder to alleviate possible side effects of therapy with IBAT inhibitor compounds, such as for instance diarrhoea. The bile acid binder may be formulated for colon release.

L'invention concerne une formulation pharmaceutique comprenant un composé inhibiteur du transport iléal des acides biliaires, un inhibiteur des HMG CoA-réductases, ainsi qu'un excipient, acceptable sur le plan thérapeutique. Cette formule est caractérisée en ce qu'elle est conçue pour apporter l'inhibiteur du transport iléal des acides biliaires dans l'iléon, et l'inhibiteur des HMG CoA-réductases de manière non spécifique dans le tractus gastro-intestinal. Le composé inhibiteur du transport iléal des acides biliaires et l'inhibiteur des HMG CoA-réductases peuvent également être administrés en combinaison avec un liant des acides biliaires, aux fins d'atténuation des effets secondaires possibles -tels que la diarrhée- d'une thérapie à l'aide des composés inhibiteurs du transport iléal des acides biliaires. Le liant des acides biliaires peut être formulé de manière à être libéré dans le colon.

Affiliated with

Also associated with

Rating

Oral formulation comprising an inhibitor compound of the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oral formulation comprising an inhibitor compound of the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral formulation comprising an inhibitor compound of the... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1952634