C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/04 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2688321
Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bi cyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
L'invention concerne des nucléosides bicycliques comprenant un groupe amino substitué dans la liaison, des composés oligomères possédant au moins un de ces nucléotides bicycliques et des procédés d'utilisation des composés oligomères. Les nucléosides bicycliques comprenant un groupe amino substitué dans la liaison sont utiles pour améliorer les propriétés des composés oligomères telles que la résistance aux nucléases, et dans certains modes de mise en oeuvre, les composés oligomères s'hybrident à une partie d'un ARN cible, entraînant la perte de la fonction normale de l'ARN cible.
Bhat Balkrishen
Prakash Thazha P.
Swayze Eric E.
Isis Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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