Zinc finger-reactive antimicrobial compounds

Details Zinc finger-reactive antimicrobial compounds Zinc finger-reactive antimicrobial compounds

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) C07D 239/48 (2006.01) C07D 239/545 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2345212

The invention relates to antimicrobial compounds which interact with zinc in a zinc finger of a bacterial DNA polymerase, methods of screening for such compounds, and methods of using such compounds to inhibit polymerase activity or bacterial growth.

L'invention concerne des composés antimicrobiens qui interagissent avec le zinc présent dans un doigt de zinc d'une polymérase ADN de bactérie, des procédés de criblage de ces composés et des procédés d'utilisation de ces mêmes composés pour inhiber l'activité de la polymérase ou la croissance des bactéries.

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