Process for preparing enantiomerically pure indolopyridines

Details Process for preparing enantiomerically pure indolopyridines Process for preparing enantiomerically pure indolopyridines

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01)

Patent

CA 2717381

The invention relates to a novel process for the preparation of pharmacologically interesting indolopyridine derivatives containing tetracyclic tetrahydro-.beta.-carboline-hydantoines linked to a basic side chain and the corresponding salts, which can be used as Eg5 inhibitor, with very high overall chemical yield and enantiomeric purity.

L'invention porte sur un nouveau procédé de préparation de dérivés d'indolopyridine pharmacologiquement intéressants, contenant des tétrahydro-ß-carboline-hydantoïnes tétracycliques liées à une chaîne latérale basique et des sels correspondants, qui peuvent être utilisés comme inhibiteur de Eg5, avec un rendement chimique global et une pureté énantiomérique très élevés.

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