A novel inhibitor of beta amyloid cleavage enzyme

Details A novel inhibitor of beta amyloid cleavage enzyme A novel inhibitor of beta amyloid cleavage enzyme

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/08 (2006.01) A61P 25/28 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2372377

This invention relates to a novel inhibitor of beta amyloid cleavage enzyme (BACE, transmembrane aspartyl protease beta-secretase, beta site APP cleavage enzyme, memapsin-2, BACE-1), pharmaceutical compositions containing it and its use in the treatment of neurological disorders such as Alzheimer's disease, Crutzfield-Jacob's disease, prion disorders, amyotrophic lateral sclerosis, progressive supranuclear palsy, head trauma, stroke, down's syndrome, pancreatitis, inclusion body myocitis, other peripheral amyloidoses and diabetes.

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