C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/46 (2006.01) C07C 233/66 (2006.01)
Patent
CA 2548020
The invention relates to methods for producing (3-oxo-2,3-dihydro-1H-isoindol- 1-yl) acetylguanidine derivatives of formula (I) using 3-hydroxy-2,3-dihydro-1 H-isoindol-1-one derivatives or 3-(2-carbamoyl-phenyl) acrylic acid ester derivatives as intermediate stages, to a method for the resolution of racemates and to intermediate products of the inventive method.
La présente invention concerne des procédés pour produire des dérivés de (3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acétylguanidine de formule (I), en utilisant des dérivés de 3-hydroxy-2,3-dihydro-1H-isoindol-1-one ou des dérivés d'ester d'acide 3-(2-carbamoyl-phényl)-acrylique en tant que produits intermédiaires, un procédé de séparation des produits racémiques, ainsi que des produits intermédiaires des procédés selon cette invention.
Gouraud Yves
Hanna Reda
Huang Bao-Guo
Keil Johannes
Kleemann Heinz-Werner
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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