Therapeutic piperazines as pde4 inhibitors

Details Therapeutic piperazines as pde4 inhibitors Therapeutic piperazines as pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07D 241/08 (2006.01) C07D 243/08 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 405/08 (2006.01)

Patent

CA 2644069

The invention includes a compound of formula I; wherein R1, X, Z, n, and m have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function in animals.

La présente invention concerne un composé de formule I : dans laquelle R1, X, Z, n et m ont l'une quelconque des significations indiquées dans le présent document, ainsi que les sels de tels composés, des compositions comprenant de tels composés et des méthodes thérapeutiques qui comprennent l'administration de tels composés. Les composés selon l'invention sont des inhibiteurs de la fonction de PDE4 et sont utiles pour améliorer les fonctions cognitives chez l'animal.

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