A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7105 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2708686
The present invention relates to methods for treating TTK positive breast cancers or soft-tissue sarcomas in a mammalian subject by administering a therapeutically effective amount of a TTK antagonist. The invention also provides compositions comprising a TTK antagonist and a HER-2 antagonist, as well as methods of diagnosing a basal-like breast cancer and methods of determining the prognosis of a subject having a cancer by assessing expression of TTK in a tumor sample from a subject.
L'invention porte sur des méthodes de traitement de cancers du sein TTK-positifs ou de sarcomes des tissus mous par administration d'une dose à effet thérapeutique d'un antagoniste du TTK. L'invention porte également: sur des compositions comprenant un antagoniste du TTK et un antagoniste du HER-2, sur des méthodes de diagnostic de cancers du sein de type basal, et sur des méthodes d'établissement du pronostic chez un patient cancéreux en évaluant l'expression de TTK dans un échantillon de tumeur.
Pan Guohua
Gowling Lafleur Henderson Llp
University Health Network
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