C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/205 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 271/42 (2006.01) C07C 271/44 (2006.01) C07D 213/56 (2006.01) C07D 263/24 (2006.01) C07D 279/12 (2006.01)
Patent
CA 2361162
Disclosed are compounds which bind .alpha.4.beta.7 integrin. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by .alpha.4.beta.7 integrin. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
L'invention porte sur des composés se fixant à l'intégrine .alpha.¿4?.beta.¿7? dont certains inhibent également l'adhésion de leucocytes et en particulier celle médiée par l'intégrine .alpha.¿4?.beta.¿7?. Ces composés sont utiles pour le traitement de maladies inflammatoires chez les mammifères dont l'homme, tels que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence sidéenne, le diabète, la maladie intestinale inflammatoire, la polyarthrite rhumatoïde, les transplantations de tissus, les métastases tumorales, et l'ischémie du myocarde, ainsi que pour le traitement d'affections cérébrales inflammatoires.
Konradi Andrei
Pleiss Michael A.
Thorsett Eugene D.
Elan Pharmaceuticals Inc.
Torys Llp
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