Methods of making 21-[4'-(nitrooxyalkyl)benzoate]...

Details Methods of making 21-[4'-(nitrooxyalkyl)benzoate]... Methods of making 21-[4'-(nitrooxyalkyl)benzoate]...

C - Chemistry, Metallurgy

07

C

C07C 53/44 (2006.01) C07C 57/30 (2006.01) C07C 57/72 (2006.01) C07J 5/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2448296

The present invention provides methods of making 21-[4'- (nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme. The invention also provides intermediates useful in making such 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives as well as methods for making such intermediates.

L'invention concerne des procédés de fabrication de dérivés de corticostéroïde 21-[4'-(nitrooxyalkyl) benzoate] selon le schéma de réaction général suivant. L'invention concerne aussi des intermédiaires utilisés dans la synthèse des dérivés de corticostéroïde 21-[4'-(nitrooxyalkyl) benzoate] ainsi que des procédés pour fabriquer ces intermédiaires.

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